Clinical Trials/Research Opportunities

Neuromodulation-related Clinical Trial/ Research Study Opportunities

Below are neuromodulation-related research studies that are currently recruiting participants.


Repetitive Transcranial Magnetic Stimulation for Adolescent Depression

We are seeking adolescents (age 12-18 years) with depression that has not improved with at least 1 medication to participate in a research study at the University of Minnesota. Study activities include clinical interviews, 20 sessions (5 days/week, ~20 minutes/day) of either repetitive transcranial magnetic stimulation (rTMS) or sham, and 2 brain MRI scans. After the 20 sessions, all participants will be told if they had gotten active rTMS or sham, and will have the option of participating in a second phase to receive active rTMS (no sham). For more information and to find out if you or your child would qualify for our study, please call 612-626-8534.


Pathophysiology of Spasmodic Dysphonia: A Transcranial Magnetic Stimulation (TMS) study

The Department of Rehabilitation Science at the University of Minnesota is currently conducting a research study titled: Pathophysiology of Spasmodic Dysphonia: a TMS study. The purpose of the study is to better understand the differences in cortical excitability between healthy individuals and those diagnosed with spasmodic dysphonia.

Healthy people and people with spasmodic dysphonia could be eligible to participate. The study requires two ~2 hour appointments at the University of Minnesota in Minneapolis. Compensation is able to be provided for your participation for the amount of $100.

If you are interested in participating or have any questions regarding this study, please contact:

Rebekah Schmidt by phone: (612)626‐0637 or by email:


A randomized pilot study assessing vagus nerve stimulation during rehabilitation for improved upper limb motor function after stroke (MicroTransponder’s Vivistim System)

The Program of Physical Therapy and Rehabilitation Science at the University of Minnesota is currently conducting a research study in stroke rehabilitation. The purpose of the study is to assess the therapeutic potential of a device similar to a cardiac pacemaker combined with intensive therapy. The aim of this study is to improve arm function in patients who are between the ages of 30-80 that have had a stroke greater than 4 months and less than 5 years ago.

 Learn more information about this study at or contact Cecilia Prudente at (612) 900-8794 or via email at

 Stroke Research with Brain Stimulation

We are seeking individuals who have had a stroke 3 months to 12 months ago to participate in a research study involving stimulation to the brain to improve hand function.

To learn more about this study and how to participate, please contact Nessa Johnson at or 612-624-1094.

Pediatric Motor Cortex Location Study

Non-invasive brain stimulation (NIBS) is a form of painless stimulation that has potential to improve movement. Determining the optimal location to apply non-invasive brain stimulation in the brain is critical to maximize the potential of the intervention. We can measure this location using a non-invasive brain stimulation test or by conventional means measuring head size and landmarks.

This study will investigate the potential differences in using those two measurements to determine the location for future placement of electrodes in studies applying non-invasive brain stimulation as a potential intervention aimed to improve the hand function for children with hemiparesis.

 Please visit our website to learn more:

We invite you to contact us at 612-626-6415 or for more information with no obligation to participate.

Title: Comparing the Location of the Motor Cortex in Children Using Two Methods: EG and TMS. ( NCT02015338)

Pediatric Brain Stimulation and Hand Training

Research using brain stimulation on the outside of the head (non-invasive) has shown improvements in recovery of motor function. In this research study we are combining a form of non-invasive brain stimulation called Transcranial Direct Current Stimulation (tDCS) with a therapy for hand function called Constraint-Induced Movement Therapy (CIMT).

Using tDCS, the brain cells that were inactive due to stroke have the potential to become active and contribute to improving function of the weaker hand.

The goal of this study is to determine if combining CIMT and TDCS has a greater impact on improving hand function then CIMT alone.

Please visit our website to learn more:

We invite you to contact us at 612-626-6415 or for more information with no obligation to participate.

Title: Synergistic Effect of Combined tDCS/CIMT in Children with Hemiparesis. ( NCT02250092)


Tinnitus Research with Acoustic and Noninvasive Neural Stimulation

The University of Minnesota’s Departments of Biomedical Engineering and Otolaryngology are seeking individuals who have tinnitus to participate in research involving acoustic stimulation, electrical stimulation of different skin surface regions, and noninvasive brain stimulation to potentially decrease the tinnitus percept. Participation involves up to 16 testing sessions that typically occur once every 1-2 weeks at the University of Minnesota. Each testing session will require up to 3 hours. Participants will complete questionnaires, perform several tests to determine their hearing and tinnitus characteristics, be presented with different stimulation paradigms, and describe changes in their tinnitus from the different tests.

Participants must be an adult between 18 and 65 years of age, have tinnitus preferably for less than 5 years, have no history of seizures, not be pregnant, and not have any implantable devices or indwelling metal. Participants will receive compensation for their participation in each testing session in the form of a $60 Visa gift card that may be used at any retailer that accepts Visa. The first informational visit will take approximately 1.5 hours and will be compensated with a $40 Visa gift card. There is no charge for participating in this research. For more information, please contact Hubert Lim, Ph.D., at

Study Flyer (pdf)

Brain Function in Healthy Volunteers

Transcranial Current Stimulation of the Human Brain

The purpose of our study is to combine noninvasive brain stimulation with noninvasive brain recording to investigate how stimulation affects brain activity.

To learn more about the study, please contact the study coordinators for more information: Bryan Baxter ( and Jeet Roy (