Program Staff

Dori Henderson Photo

Dori Henderson, Ph.D.

MnDRIVE Brain Conditions Program Manager
6-145 Jackson Hall
(612) 626-2321

Katie Sanders

Deep Brain Stimulation Clinical Program Coordinator
Department of Neurology
(612) 626-9302
Kelly Ryberg

Kelly Ryberg, M.A., CCRP

Research Coordinator - Deep Brain Stimulation Clinical Trials
Department of Neurology
(612) 626-3439
Krista Sands

Krista Sands, Ph.D.

Research Coordinator - Deep Brain Stimulation Clinical Trials
Department of Neurology
(612) 626-3525
Mo Chen photo

Mo Chen, Ph.D.

Scientist & Manager, MnDRIVE Non-invasive Neuromodulation Laboratory
Room 247, 717 Delaware St. SE.
(612) 624-5220
Angeliki Beyko photo

Angeliki Beyko, M.S.

Principal Laboratory Technician for Non-invasive Neuromodulation Studies, Center for Neuroengineering
1-205 Nils Hasselmo Hall
(612) 625-7209
Erin photo

Erin Larson, Ph.D.

Research Associate and Manager, MnDRIVE Optogenetics Core Facility
4-114 Wallin Medical Biosciences Building
(612) 624-3075
ethan

Ethan Huffington

Technician, MnDRIVE Optogenetics Core Facility
4-220 Wallin Medical Biosciences Building
(612) 624-3075

Researchers

James Carey, Ph.D., P.T.

James Carey Photo
Neuromodulation Researcher, Professor — Physical Med & Rehabilitation
377 Ch R C
(612) 626-2746

Dr. Carey’s neuromodulation interests are in applying noninvasive transcranial magnetic stimulation (TMS) to people with stroke to improve the excitability of surviving motor neurons and thereby improve their recovery of hand movement.

Wei Chen, Ph.D.

Neuromodulation Researcher, Professor - Radiology/CMRR
1-211E CMRR
(612) 625-8814

Scott Cooper, M.D., Ph.D.

Scott Cooper Photp
MnDRIVE Neuromodulation Scholar, Assistant Professor — Department of Neurology
PWB 12-154
(612) 626-9516

I am a clinical neurologist specializing in movement disorders and a research physiologist specializing in control of voluntary movement. My long term goal is to combine the two roles fruitfully. I study pathophysiology of the extrapyramidal motor system with a particular focus on basal ganglia and Parkinson's disease and on deep brain stimulation. My research is with human subjects and I collaborate extensively with bioengineers, neurosurgeons, and neuropsychologists.

Emad Ebbini, Ph.D.

Emad Ebbini Photo
Neuromodulation Researcher, Professor — Electrical and Computer Engineering
EE/CSci
(612) 625-1852

We are investigating image-guided transcranial application of focused ultrasound (tFUS) to neuromodulation. We have developed a unique paradigm for tFUS utilizing our dual-mode ultrasound array (DMUA) prototypes. DMUAs are capable of subtherapeutic or therapeutic of tFUS while providing real-time monitoring and localization of its interactions with brain tissue. Our DMUA prototypes have been shown to detect and localize both mechanical and thermal tFUS-tissue interactions with brain tissues in a rat model in vivo.

Stephen Engel, Ph.D.

Neuromodulation Researcher, Professor - Psychology
N218 Elliott Hall
(612) 625-5571

Dr. Engel's lab studies neuroplasticity in the human visual system. We use environmental manipulations, including augmented reality, to try to modulate function of the visual brain.

Bernadette Gillick, Ph.D., P.T.

Bernadette Gillick
Neuromodulation Researcher, Assistant Professor — Physical Med & Rehabilitation
Room 282 ChRB
(612) 626-3121

Research interests in cortical plasticity and recovery from neurologic insult in both adult and pediatric populations. Her research encompasses the use of different forms of non-invasive brain stimulation (transcranial magnetic stimulation and transcranial Direct Current stimulation), in combination with behavioral training, for improved motor function. Current Teaching Responsibilities include Research, Pediatric Rehabilitation, and Professional Behaviors in Academia.

Noam Harel, Ph.D.

Noam
Neuromodulation Researcher, Associate Professor, Radiology/CMRR
(612) 625-8399

My current research focuses on the development and integration of 7T MRI and high-field neuroimaging data into deep brain stimulation (DBS) surgical navigation in particular and brain surgery in general. We are developing new structural/anatomical imaging  which are combined with post processing image analysis schemes for the creation of a 3-dimensional anatomical  model of the brain. This 3D model created by the 7T images allows us to literally ‘see’ the individual shape, size and orientation of the brain target area for DBS therapy.

Matthew D. Johnson, Ph.D.

Matthew Johnson photo
Neuromodulation Researcher, Assistant Professor — Biomedical Engineering
6-134 NHH

My group is primarily interested in developing and refining neural interface technologies to improve the quality of life for people with movement disorders. Deep brain stimulation (DBS) is one such technology, which over the past twenty years has helped numerous patients with Parkinson’s disease, dystonia, and essential tremor reclaim control over their motor function. The therapy involves placing small electrodes in regions of the brain that exhibit pathological activity, which contributes to the movement disorder, and then stimulating those regions with continuous pulses of electricity. My lab focuses on understanding how the brain responds and adapts to such stimulation-based therapies from a combination of computational and experimental perspectives. The knowledge gained from these studies in turn provides us with a framework to develop, evaluate, and translate new approaches for improving patient outcome.

Teresa Jacobson Kimberley, Ph.D., P.T.

Teresa Jacobson Kimberley photo
Neuromodulation Researcher, Associate Professor — Physical Med & Rehabilitation
376 Children's Rehab Center
(612) 626-4096

Dr. Kimberley is a clinical research scientist with expertise in neuroimaging and neuromodulation in patients with neurologic disorders, particularly focal dystonia and stroke. These non-invasive techniques can help us understand the physiology of a disorder as well as be used as an adjunct to rehabilitation to improve patient’s function.  Current work is determining who is likely to respond positively to the neuromodulation therapies. 

Juergen Konczak, Ph.D.

Juergen Konczak photo
Neuromodulation Researcher, Professor — Kinesiology
400 Cooke Hall
(612) 624-4370

I am the head of a laboratory with a research focus on sensorimotor dysfunction in neurological diseases. We are actively engaged in developing new behavioral treatment options that can supplement or augment existing therapies. Currently we investigate how neuromodulation affects haptic perception in Parkinson's disease and how it changes voice quality for patients with a dystonic voice disorder called spasmodic dysphonia

Esther Krook-Magnuson, Ph.D.

Esther Krook-Magnuson Photo
MnDRIVE Neuromodulation Scholar, Assistant Professor — Neuroscience
4-160 Jackson Hall
(612) 301-7747

Neuronal networks, diversity, and specificity of function are important to both physiological processes and neurological disorders, including epilepsy.  My laboratory seeks to improve our understanding of how cells interact within a network, how networks interact with each other, and the physiological roles of neuronal populations.  In this regard, key questions remain in epilepsy research, including what are the principal networks, conditions, and cell types involved in initiating, sustaining, propagating, terminating, and potentially suppressing, seizures.  By improving our understanding of these, we improve the prospects of someday reaching the goal of no seizures, no side effects, for all epilepsy patients.  My lab uses rodent models of neurological disorders, including temporal lobe epilepsy, and techniques including electrophysiology, optogenetics, immunocytochemistry, transgenic animals, and behavioral experiments to address these fundamental questions.

Vipin Kumar, Ph.D.

Vipin Kumar photo
Neuromodulation Researcher, Professor & Head — Computer Science and Eng
Room 4-192C KHKH
(612) 625-0726

Vipin Kumar is currently William Norris Professor and Head of the Computer Science and Engineering Department at the University of Minnesota. Kumar's current research interests include data mining, high-performance computing, and their applications in Neuroscience, Climate/Ecosystems and Biomedical domains. In the context of human neuroscience, the focus is on functional connectivity and its dynamics in healthy, disease, and post-treatment conditions. Functional connectivity analysis techniques developed in his group are highly suited for assessing the effectiveness of neuromodulation in treating mental disorders.

Wynn Legon, Ph.D.

Wynn Legon Photo
MnDRIVE Neuromodulation Scholar, Assistant Professor — Physical Med & Rehabilitation
ChRC 398
(612) 626-1183

Dr. Legon’s laboratory researches methods of non-surgical brain neuromodulation in humans including focused ultrasound, transcranial electric current stimulation and transcranial magnetic stimulation (TMS). His laboratory uses functional magnetic resonance imaging (fMRI), electroencephalography (EEG) as well as computational models to better understand how these methods of non-surgical neuromodulation affect whole brain networks and specific neuronal circuits during a variety of sensory, motor and cognitive tasks. It is the goal of his research to develop and improve tools for the modulation of human brain circuit activity to support functional brain mapping efforts and to advance diagnostics and therapies in neuroscience.

Mo Li, Ph.D.

Mo Li
Neuromodulation Researcher, Assistant Professor - Electrical and Computer Engineering
5-127 Keller Hall
(612) 625-4873

Hubert Lim, Ph.D.

Hubert Lim
Neuromodulation Researcher, Assistant Professor- Biomedical Engineering
6-132 Nils Hasselmo Hall
(612) 626-4565

Shalom Michaeli, Ph.D.

Shalom Michaeli photo
Neuromodulation Researcher, Associate Professor — Radiology - CMRR
2-122 CMRR Building
(612) 625-8397

The goal of my research is to utilize novel DBS paradigms based on the generation of rotating fields by amplitude and frequency modulated pulses, for efficient low energy modulation of thalamic – cortical pathways. The general objective is to optimize DBS pulse shapes to generate excitation of selective neuronal populations. The work on animal models is critical for the translation of more efficient and safer DBS strategies to humans. Development of novel efficient schemes which allow for flexible and selective excitability of cell’s and axonal populations is critical. The detection of network level activity leaded to a breakthrough development of resting state functional MRI (rsfMRI) methodologies. Our preliminary studies demonstrate that strikingly different functional connectivity outcomes can be robustly measured by fMRI in rest and activated conditions upon different DBS paradigms, thus substantiating the rationale for this project.

Tay Netoff, Ph.D.

Tay Netoff
Neuromodulation Researcher, Associate Professor- Biomedical Engineering
6-122 NHH
(612) 625-3618

Giuseppe Pellizzer, Ph.D.

Giuseppe Pellizzer photo
Neuromodulation Researcher, Associate Professor — Minneapolis VA Hospital, Neuroscience
6-125 Jac H
(612) 725-2283

I am interested in the neural mechanisms associated with the processing of information that leads to the production of movements. For this purpose, we combine psychophysical and neurophysiological approaches.The current projects concern (1) how the brain deals with uncertainty during motor planning; (2) the decoding of brain signals for brain-machine interface applications.

Michael Park, M.D., Ph.D.

Michael Park Photo
MnDRIVE Neuromodulation Scholar, Assistant Professor — Department of Neurosurgery
Mayo D429-4
(612) 626-4706

Dr. Park will use his background in biology, medicine, and electrical engineering to work with other university departments, such as neurology and medical bioengineering, to create new devices that increase therapeutic options for patients with brain conditions. His research interests include: brain structure,  neuromodulation/deep brain stimulation, and medical device innovation. 

David Redish, Ph.D.

David Redish photo
Neuromodulation Researcher, Professor — Neuroscience
4-142 MCB
(612) 626-3738

My main research objective is to use theory, neurophysiology, and computational modeling to understand how the brain drives behavior. My lab combines multi-electrode neural ensemble recordings from awake, behaving animals with complex computational analysis techniques that enable measurement of neural dynamics at very fast time scales (e.g. msec).   Furthering the understanding of the neural mechanisms that underlie decision-making allows us to modulate those decision-making processes, behaviorally as well as neurally.

Patrick Rothwell, Ph.D.

Patrick Rothwell
MnDRIVE Neuromodulation Scholar, Assistant Professor - Department of Neuroscience
4-142 WMBB
(612) 626-8744

Brain disorders and mental illness represent a tremendous social and economic burden, with few effective treatments. The goal of our research is to identify the causes of brain conditions, and develop interventions to restore healthy function using synaptic plasticity and neuromodulation. We study the striatum, and important brain region for both simple and complex movements and cognitive functions. We examine the function of neural circuits formed by striatal synapses that connect specific sources and targets. Our multidisciplinary approach includes quantitative analysis of gene expression; genetic and molecular manipulations of neural circuits; measurement of synaptic function and plasticity using electrophysiology; and optogenetic stimulation of circuits in brain slices and behaving animals. Our current research focuses on autism spectrum disorders and drug addiction - two brain conditions that affect overlapping elements of striatal circuitry.

David Rottenberg, M.D.

David Rottenberg photo
Neuromodulation Researcher, Professor — Neurology
Bx 295 Mayo

I came late to neuromodulation, having been trained as a neuro-oncologist with research interests in quantitative neuroimaging and computational anatomy.  With the advent of deep brain stimulation (DBS) for the treatment of movement disorders in the 1990's I recognized an opportunity to transfer my computer skills and computational interests to programming the implanted pulse generators used for DBS.  My clinical and research interests in DBS focus on the poorly-understood high-dimensional space created by the multiple parameters — active contacts, applied voltage, pulse width, constant current, and stimulation frequency — that are routinely selected to modulate DBS in individual patients.

Mark Thomas, Ph.D.

Mark Thomas Photo
Neuromodulation Researcher, Assistant Professor - Neuroscience and Psychology
Room 6-145 JacH
(612) 624-4963

Paul Tuite, M.D.

Paul Tuite photo
Neuromodulation Researcher, Professor — Neurology
12-146 P W B
(612) 625-9662

As a founding member of the neuromodulation team when I arrived at the University of Minnesota in 1996 I am playing a crucial role in managing the medical aspects related to Parkinson's disease as well as partaking in the Deep Brain Stimulation (DBS) surgical program consensus meetings that help select appropriate individuals for DBS surgery. 

Kamil Ugurbil, Ph.D.

Kamil Ugurbil photo
Neuromodulation Researcher, Professor — Radiology-CMRR
102 CMRR
(612) 626-9591

Dr. Ugurbil is the director of the Center for Magnetic Resonance Research (CMRR) where he leads a multi-investigator and multi-disciplinary research effort focused on imaging brain anatomy, function, and connectivity with magnetic resonance (MR) techniques, particularly at ultrahigh (7 Tesla and above) magnetic fields. These techniques are increasingly important in evaluating numerous aspects of neuromodulation, such as defining circuits involved, targets for neuromodulation, consequences of neuromodulation, etc.

Jerrold L. Vitek, M.D., Ph.D.

Jerrold Vitek Photo
Neuromodulation Researcher, Professor & Head — Neurology Department, MnDRIVE Steering Committee Member
12-100 PWB
(612) 624-1903

Dr. Vitek directs a large interdisciplinary neuromodulation research program primarily centered on understanding the pathophysiology of movement disorders such as Parkinson's disease and dystonia as well as the mechanisms underlying the therapeutic effect of deep brain stimulation. Dr. Vitek serves as the principal investigator for both pre-clinical laboratory studies using animal models and clinical studies on human subjects/patients. Much of his work focuses on the ultimate translation of basic laboratory research discoveries into clinical treatment options for affected patients in order to reduce symptoms, minimize side effects and enhance function and quality of life. Dr. Vitek forms key collaborations with other experts in neurology as well as other disciplines such as neurosurgery, neuroscience, biomedical science, and radiology in addition to the medical industry to expedite and enhance new discoveries and their meaningful translation from “bench to bedside.

Angus W. MacDonald, III, Ph.D.

angus
N218 Elliott Hall
(612) 624-3813

My laboratory examines cognitive control, working memory and executive functioning and decision-making. We are using neuroimaging to decode brain regions involved in these processes, and transcranial stimulation to examine and promote plasticity in these processes. This work extends into psychopathology, such as understanding how brain stimulation can promote cognitive remediation in people with schizophrenia or predicting decisions related to addiction risk.

Leadership

Bin He, Ph.D.

Bin He Photo
Director, Center for Neuroengineering; Director, Institute for Engineering Medicine
6-124 NHH
(612) 626-1115

Neuromodulation techniques including TMS, high definition tDCS, and ultrasound modulation.

Mechanisms of neuromodulation and closed loop controlled neuromodulation systems.

TMS/EEG/fMRI and tDCS/EEG/fMRI multimodal approaches. Applications to stroke, epilepsy

and other disorders, as well as cognitive neuroscience.

Neuromodulation Fellows

Bryan Baxter

Bryan
Graduate Fellow

Department:  Biomedical Engineering
Mentor: Bin He, PhD
Project Title:  Transcranial Direct Current Stimulation (tDCS) and EEG to Probe the Relationship between Noninvasive Neuromodulation, Brain States and Learning

Bryan Baxter’s research will allow for the development of neurostimulation protocols that optimize the 
therapeutic effects of noninvasive neuromodulation

Adele DeNicola

Adele
Graduate Fellow

Department:  Graduate Program in Neuroscience

Mentor: Matthew Chafee, PhD
Project Title:   Deep Brain Stimulation (DBS) to Improve Cognition in Schizophrenia:  Effects of DBS in Mediodorsal Nucleus of Thalamus (MDT) on Cognitive Task Performance in a Non-human Primate Model of Neural and Cognitive Deficits in Schizophrenia

Adele DeNicola’s work aims to establish a new clinical application for deep brain stimulation by determining
the effectiveness of DBS in MDT for cognitive deficits in schizophrenia

Kate Frost

Graduate Fellow

Department:  Physical Medicine and Rehabilitation

Mentor: James Carey, PhD
Project Title:  Effect of different inter-pulse intervals of paired associative stimulation on cortical excitability in people with chronic stroke

Kate Frost’s work will lead to novel non-invasive neuromodulation protocals to promote movement recovery after stoke

Abbey Holt

Graduate Fellow

Department:  Graduate Program in Neuroscience

Mentor: Tay Netoff, PhD
Project Title:  Design of Stimulus Waveforms for DBS that Maximally Disrupt Pathological Oscillations seen in Parkinson’s Disease

Abbey Holt’s project will lead to improvements in DBS stimulation paradigms to better treat the motor symptoms of patients with medication-refractory Parkinson’s disease.

 

 * Abbey Holt was a recipient of a FY2014  MnDRIVE fellowship in Neuromodulation. She competed again In 2015 and received a second year of funding for her project.

Marc Pisansky

Marc Pisansky
Graduate Fellow

Department:  Psychology

Mentor: Jonathan Gewirtz, PhD
Project Title:  Optogenetically Modulated Oxytocin Signaling in a mouse model of socio-emotional cognition

Mark Pisansky’s research will advance the understanding of brain circuits involved in socio-emotional cognition and its impairments in psychiatric disease

Tonya L. Rich

Graduate Fellow

Department:  Physical Medicine & Rehabilitation

Mentor: Bernadette Gillick, PhD, MSPT, PT
Project Title:  Non-Invasive Brain Stimulation in Children with Stroke: Promoting Cortical Excitability, Motor Functioning and Community Involvement

Tonya Rich’s work will lead to innovative neuromodulation rehabilitation interventions that optimize neurorecovery and hand function in children with stroke.

Euijae Shim

Shim
Graduate Fellow

FY2015

Department:  Electrical & Computer Engineering
Mentor: Mo Li, PhD
Project Title:  Development of a minimally invasive opto-electrical probe for in vivo closed loop neuromodulation of decision-making networks in the brain

Euijae Shim’s work will develop new tools for neuromodulation and advance therapies that promote health through decision-making

Brian Sweis

Brian
Graduate Fellow

Department:  Neuroscience

Mentor:  Mark Thomas, PhD
Project Title:  Optogenetic Modulation of Decision-Making Circuitry in Mouse Models of Addiction

Brian Sweis’ research will elucidate decision-making brain circuits in healthy and neuropsychiatric states, particularly cocaine addiction

Benjamin A. Teplitzky

ben
Graduate Fellow

Department:  Biomedical Engineering

Mentor: Matthew Johnson, PhD
Project Title:  Immunohistochemical Evaluation of Synaptic Plasticity Following Deep Brain Stimulation (DBS) and Transcranial Direct Current Stimulation (tDCS)

Ben Teplitzky’s research will provide highly relevant insight regarding the cellular mechanisms that contribute to DBS and tDCS effectiveness within brain circuits

Scott Warren

Warren
Graduate Fellow

Department:  Graduate Program in Neuroscience

Mentors: Geoffrey Ghose, PhD & Stephen Engel, PhD
Project Title:  Subtle Manipulation of a Cortical Microcircuit by Targeting Stimulation to Distinct Layers of Neocortex

Scott Warren’s project will support the development of next-generation technologies designed to deliver precisely targeted stimulation that complements and enhances the brain’s innate computational processes.

YiZi Joe Xiao

Jo
Graduate Fellow

Department:  Biomedical Engineering

Mentor:  Matthew Johnson, PhD
Project Title:  Design and validation of optimization algorithms to program high-density deep brain stimulation (DBS) electrode arrays.

Joe Xiao’s project will develop efficient algorithms to program the next generation of DBS implant devices for improved treatment of Essential Tremor, Parkinson's disease, and other brain conditions.

 

Kai Yu

Kai
Graduate Fellow

Mentor:  Bin He, PhD

Project Title:  Directional Ultrasound-induced Lorentz Current Stimulation to Explore a Non-invasive, High Spatial Resolution Neuromodulation Approach

Mr. Yu’s work will lead to the development of a novel non-invasive neuromodulation technology with high spatial resolution for the management of a wide range of brain conditions

Gowtham Atluri, Ph.D.

Gowtham
Post-doctoral Fellow

Department:  Psychiatry, Computer & Electrical Engineering

Mentors: Kelvin O. Lim, MD and Vipin Kumar, PhD
Project Title:  data mining methods to study the impact of Transcranial Current Stimulation (tCS) as a treatment for refractory auditory hallucinations, a common problem in schizophrenia

Dr. Atluri's contributions will enable neuroscientists to systematically study the impact of neuromodulation procedures, and will have wide applicability to neuromodulation projects at the University and beyond

Sommer Amundsen Huffmaster, Ph.D.

sommer
Post-doctoral Fellow

Department:  Neurology

Mentor: Column MacKinnon, PhD, Noam Harel, PhD & Jerrold Vitek, MD, PhD
Project Title:  Examining the Effects of Cues and Transcranial Direct Current (tCS) on Gait and Gait Initiation in People with Parkinson's Disease Who Have Freezing of Gait

Dr. Amundsen’s patient-centered research work will lead to improved treatment for the critical motor symptoms of Parkinson’s disease

Lauri Lehto, Ph.D.

Lauri
Post-doctoral Fellow

Department:  Center for Magnetic Resonance Research

Mentors:  Shalom, Michaeli, PhD;  Jerrold Vitek, MD, PhD;  Matthew Johnson, PhD,  & Curtis Corum, PhD
Project Title:  Deep Brain Stimulation (DBS) with Alternating and Rotating Fields

Dr. Lehto’s research will  lead to the development of novel DBS pulse paradigms that are safe, energy efficient and selectively stimulate  specific neuronal populations

Jacob Montgomery, Ph.D.

Jake
Post-doctoral Fellow

Department:  Neuroscience

Mentor:  Mark Masino, PhD
Project Title:  Assessment of the Effects of Optogenetic Modulation of Catecholamine Release on Locomotor Networks

Dr. Montgomery’s research will lead to a better understanding of the locomotor circuitry 

Jerel Mueller, Ph.D.

Jerel
Post-doctoral Fellow

Department: Physical Medicine & Rehabilitation

Mentor:  Wynn Legon, PhD
Project Title:  Manipulation of electromyographic activity by transcranial-focused ultrasound stimulation of human motor cortex

Dr. Mueller’s research will provide an empirically observable metric of the cortical effects of transcranial-focused ultrasound, and will significantly advance the utility of ultrasound methods for human neuromodulation

Jing Wang, Ph.D.

Wang
Post-doctoral Fellow

Department:  Neurology

Mentor: Jerrold Vitek, MD,PhD
Project Title:  Plasticity Mediated Improvement of Motor Symptoms with “Coordinated Reset” and Other Novel Deep Brain Stimulation (DBS) Paradigms for Parkinson’s: Relationship of Stimulation Voltage and Treatment Duration to the Magnitude and Duration of Enduring Therapeutic Benefit.

Dr. Wang’s research will advance the field of neuromodulation through the development of new DBS algorithms designed to induce plasticity in motor circuits and lead to enduring therapeutic improvement of motor symptoms; her studies will enhance our understanding of Parkinson’s disease pathophysiology and the mechanisms that underpin the therapeutic effects of DBS in the Parkinsonian state

Wilson Yu, Ph.D.

Wilson Yu photo
Post-doctoral Fellow

Department:  Neuroscience

Mentor:  Esther Krook-Magnuson, PhD
Project Title:  Examining the Mechanisms Involved in the Efficacy of On-demand Cerebellar Optogenetic Neuromodulation in a Mouse Model of Temporal Lobe Epilepsy

Dr. Yu’s research will translate to improved treatments for patients suffering from drug-resistant temporal lobe epilepsy

David Darrow, M.D., M.P.H.

Darrow
Resident/Clinical Fellow

Department:  Neurosurgery

Mentor: Tay Netoff, PhD & Michael Park, MD, PhD
Project Title:  Application of Dual Mode Ultrasound Array for High-Resolution Neuromodulation of Seizure Suprpression Targets

Dr. Darrow’s research will lead to the development of a method to rapidly explore new targets for neuromodulation as well as prognosticate for DBS in epilepsy, movement disorders, and psychiatric diseases without requiring invasive surgery

Adel El-Nashar, M.D.

Adel
Resident/Clinical Fellow

Department:  Neurosurgery

Mentor: Andrew Grande, PhD
Project Title:  DBS Targeting – Validation of High ffeld MRI DTI Studies of Thalamic and Hypothalamic Structures and Circuits Through Microscopic Sections and Neuroanatomic Dissections in Cadaveric Brains, with Subsequent Evaluation of Neuroanatomical Variability across Individuals

Dr. El-Nashar’s research will lead to a refinement of knowledge of neuroanatomical brain mapping and improved precision in targeting and stimulation for Deep Brain Stimulation (DBS), Dr. El-Nashar will also receive clinical training in the assessment and medical management of patients eligible for, or who have undergone DBS

Khadijah F. Shamseddine, M.D.

Shamsiddine
Resident/Clinical Fellow

Department:  Neurology

Mentor: Anthony Santiago, MD & Jerrold Vitek, MD, PhD
Project Title: Comparison of Targeting Accuracy with High Field (7T) vs Standard (1.5T) Pre-operative Imaging, and Assessment of Intraoperative Neurophysiological Predictors of Post-operative Deep Brain Stimulation (DBS) Side-effect Thresholds

Dr. Shamseddine’s work will establish appropriate preoperative imaging protocols for optimizing the anatomical accuracy of electrode placement, and provide her with clinical training in the selection and medical management of patients who have undergone DBS