Projects

A Novel GABAergic Projection from the Hippocampus to the Supramammillary Area

Lauren Glassburn's project will characterize a novel hippocampal projection that would reveal how the hippocampus can influence another brain region, the supramammillary area, which has the potential to modulate identification and memory encoding of familiar and novel environments.

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Cerebello-hippocampal interactions via the supramammillary area

Shayne Hastings' project will examine the connections and understudied intermediary regions between the cerebellum and hippocampus and how those may contribute to the development of novel targets for seizure intervention via neuromodulation.

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Cerebellum-forebrain circuitry underlying anxiety/depression-like behavior in a social isolation mouse model

Dr. Pathak aims to identify the neurocircuits responsible for this vulnerability which will establish the cerebellum as a new locus for psychiatric disorders predisposed by adolescent social stress.

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Characterizing the pathophysiology across the pallido-cortical network and therapeutic pathway activation in dystonia using directional stimulation

Dr. Alberico's project aims to examine the intra-operative of neural activity in the motor and sensorimotor circuits as well as determining DBS pathway activation that will be used to determine optimal DBS parameters for treating patients with dystonia.

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Closed-loop renal nerve block for treatment of resistant hypertension

Dzifa Kwaku’s research project aims to develop a reversible and adjustable neuromodulation technique to precisely regulate the activity of renal nerves based on a feedback system to control blood pressure by modulating communication between the kidney and the brain.

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Developing neuromodulation targets for reward pursuit and threat avoidance with human intracranial electrophysiology

Blair Vail's research project investigates the neural mechanisms underlying mental health disorders by identifying the role of specific brain areas in these processes, which can then be targeted by brain stimulation, several forms of which are non-invasive and low risk.

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Examining the prefrontal basis of explore-exploit transitions in humans as a putative neuromodulation target for cognitive flexibility

Dr. Yan's project will examine whether neural signatures in the prefrontal cortex of explore-exploit transitions represent potential neuromodulation targets for improving cognitive flexibility with intracranial recordings and stimulation in humans.

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Exploring longitudinal changes in cognitive control, and its LFP correlates, in patients receiving deep brain stimulation for OCD

Dr. Olsen's project investigates how cognitive and neural processes are enhanced over time with deep brain stimulation and how it will lead to improved outcomes for individuals suffering from severe mental illness.

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Functional Characterization of iPSC-Derived Cell Types for In Vitro Modeling of Spinal Cord Injury and Chronic Pain

Anne Huntemer-Silveira's research project lays the foundation for the development of a unique stem cell model that can be used to study sensory circuitry in the spinal cord.

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Implantable Magnetic Microcoils (μcoils) For Cellular-Level Treatment of Neurological Disorders

Renata Saha's project aims to develop a device using microcoils (μcoils), which provides magnetic stimulation with the focality of an implantable electrode but works on the physics of transcranial magnetic stimulation (TMS).

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Projects

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