Closed-loop renal nerve block for treatment of resistant hypertension

High blood pressure (hypertension) is a clinical problem if left uncontrolled can damage organs in the body, leading to poor quality of life and cardiac events such as a heart attack or stroke. Currently, 26% of adults in Minnesota have hypertension, with over 75% reporting that they take blood pressure medications. Dzifa Kwaku’s research project aims to develop a reversible and adjustable neuromodulation technique to precisely regulate the activity of renal nerves based on a feedback system to control blood pressure by modulating communication between the kidney and the brain. She also will be partnering with CorTec and Heraeus Medical Components for the development of this novel technology to create a nerve cuff system. Successful development of this novel closed loop electroceutical technology can enhance neural target engagement which will lead to improved treatments for hypertensive patients in Minnesota. This technology can also be applied to modulate other organs for the treatment of cardiometabolic diseases.

Graduate Fellow: Dzifa Kwaku, Biomedical Engineering

Mentor: Matthew Johnson, Ph.D. & Hubert Lim, Ph.D., Biomedical Engineering