The Effects of Parkinsonism and Pallidal Deep Brain Stimulation on Cortical Dynamic Functional Connectivity

Parkinson’s disease affects more than 10 million people worldwide and about 13,400 people in Minnesota, and it greatly reduces the quality of human life and increases the economic burden for both individuals and society. Dr. Yang’s translational research project will improve our understanding of cortical network dysfunction in Parkinson’s disease (PD) and lead to more effective neuromodulation therapies for PD patients. This project will also improve the understanding of cortical neuronal changes related to parkinsonian bradykinesia and investigates DBS effect for PD bradykinesia. Her research will provide the rationale for the development of better neuromodulation therapies for PD that would improve the quality of life and reduce the patient management burden.

Postdoctoral Fellow: Lingling Yang, Ph.D., Neurology

Mentor: Jerrold Vitek, M.D., Ph.D., Neurology.